Simultaneous genetic analysis of longitudinal means and covariance structure in the simplex model using twin data.
نویسندگان
چکیده
A longitudinal model based on the simplex model is presented to analyze simultaneously means and covariance structure using univariate longitudinal twin data. The objective of the model is to decompose the mean trend into components which can be attributed to those genetic and environmental factors which give rise to phenotypic individual differences and a component of unknown constitution which does not involve individual differences. Illustrations are given using simulated data and repeatedly measured weight obtained in a sample of 82 female twin pairs on six occasions.
منابع مشابه
Netherlands Journal of Psychology | Ge Covariance in a Longitudinal Twin Design 81 Accommodation of Genotype- Environment Covariance in a Longitudinal Twin Design
Authors: Johanna m. de Kort* , Conor V. Dolan*,** and Dorret I. boomsma** In the classical twin study, genetic and environmental influences on a phenotype are usually estimated under the assumption that genotype-environment covariance (Ge covariance) is absent. We explore possibilities to accommodate Ge covariance in longitudinal data using the genetic simplex model. First, the genetic simplex ...
متن کاملThe genetic analysis of repeated measures. I. Simplex models.
The well-known simplex model is extended to a model that may be used for the genetic and environmental analysis of covariance structures. This "double" simplex structure can be specified as a LISREL model. It is shown that data which give rise to a simplex correlation structure, such as repeated-measures data, do not fit a factor-analysis model. The parameter estimation of the simplex model is ...
متن کاملGE Covariance Through Phenotype to Environment Transmission: An Assessment in Longitudinal Twin Data and Application to Childhood Anxiety
We considered identification of phenotype (at occasion t) to environment (at occasion t + 1) transmission in longitudinal model comprising genetic, common and unique environmental simplex models (autoregressions). This type of transmission, which gives rise to genotype-environment covariance, is considered to be important in developmental psychology. Having established identifying constraints, ...
متن کاملCauses of stability of aggression from early childhood to adolescence: a longitudinal genetic analysis in Dutch twins.
This study investigated the contribution of genetic and environmental influences on the stability of aggressive behavior from early childhood to adolescence. Two developmental models, the simplex model and the common factor model, were tested to study the underlying processes of stability and change. Measures of aggressive behavior (AGG) were obtained from maternal CBCL data as part of a large ...
متن کاملLifetimegenetic analysis of milk yield in Iranian Holstein cows using repeatability and pre-structured multivariate models
Milk yield records from 1st to 5th lactations of Iranian Holstein cows were analyzed using repeatability and a number of multivariate models that varied in additive genetic variance structure. A total of313,006 milk yield records were used. The records were obtained from 116,531 cows born between 2001 and 2005. The animals originated from 2,355 sires and 91,212 dams. A multivariate model with h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Behavior genetics
دوره 21 1 شماره
صفحات -
تاریخ انتشار 1991